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Gillingham
SNAP-tag can be used alongside other tags like CLIP-tag for multicolor labeling
Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C27H50N8O10 Molecular Weight 646
Product Name Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C67H86FN9O21 Molecular Weight 1372
066 Purity (HPLC) >= 95% Solubility DMSO
DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan payload GillinghamSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
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