Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-MMAE Size:10mg Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS

Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C102H154N14O26 Molecular Weight 1992

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

418 SMILES OC(=O)CCN1CCN(CC1)C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

722 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Thalidomide-O-acetamido-C4-azide Synonyms Thalidomide-4'-O-acetamido-C4-azide CAS Number 2098488-36-7 Related CAS Molecular Formula C19H20N6O6 Molecular Weight 428

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-MMAE Size:10mg Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly