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Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C72H95FN12O23 Molecular Weight 1515
and bioconjugation
The TMP-tag is based on the tight binding between trimethoprim (TMP)
a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility
Product Name 4-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}butanoic acid Synonyms CAS Number 1240619-81-1 Related CAS Molecular Formula C13H24N2O4 Molecular Weight 272
Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The
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