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Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates
Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360
Product Name BG-BCN Synonyms SNAP-BCN CAS Number Related CAS Molecular Formula C24H26N6O3 Molecular Weight 446
as the acetylation masks the hydroxyl groups critical for fluorescein’s fluorescence
784 Purity (HPLC) >= 95% Physical Appearance Red Solid Optical Properties Abs/Em Maxima: 550/575nm Solubility DMSO
Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP fmoc Linker substitution influences succinimide ringSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or
