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ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1
Product Name DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C115H170N14O30 Molecular Weight 2228
546 Purity (HPLC) >= 95% Solubility DMSO
Product Name: Cy3 alkyne trisulfo Synonyms: Cy3 alkyne
1038/s41589-020-0594-x
Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE payload ZXH-1-161 is a potent cereblonSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
