Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan deuterium-labeled-aldehyde 354 SMILES OCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

354 SMILES OCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-CO-C4-azide Synonyms Pomalidomide-4'-CO-C4-azide CAS Number n/a Related CAS Molecular Formula C18H18N6O5 Molecular Weight 398

it showed no significant change in labeling kinetics

Product Name Thalidomide-O-acetamido-PEG4-OH Synonyms Thalidomide-4'-O-acetamido-PEG4-OH CAS Number n/a Related CAS Molecular Formula C23H29N3O10 Molecular Weight 507

Product Name 2-Chloro-1-(methoxy-d3)-3-nitrobenzene Synonyms CAS Number n/a Related CAS Molecular Formula C7H6ClNO3 Molecular Weight 190

Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan deuterium-labeled-aldehyde 354 SMILES OCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,