Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan protac 092 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

092 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

emission maximum = 525 nm

NCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(=CC=C12)N1CCNCC1 Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

Sulforhodamine 101 is particularly well suited for excitation by the 568 nm spectral line of the Ar – Kr mixed gas laser commonly used in many confocal laser-scanning microscopes or the 594 nm spectral line of the orange He-Ne laser

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan protac 092 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by