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Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE ca S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS Number

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Description

S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS Number 2375432-97-4 Related CAS Molecular Formula C35H56ClN5O9S Molecular Weight 758

which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives

Product Name Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C46H74N8O17 Molecular Weight 1011

Product Name 5-(Methoxy-d3)-2-methylaniline Synonyms CAS Number n/a Related CAS Molecular Formula C8H11NO Molecular Weight 140

It is preferred for some complicated biological applications where reproducibility is more critical since the minor positional difference between 5-ROX and 6-ROX might significantly affect some biological properties of the underlying conjugates

Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE ca S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS NumberSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl

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